Brain Bioenergetics

 
 
 
 

  1. Neurons are cells that contain mitochondria.
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  3. By utilizing the science of photobiomodulation to energize neuronal mitochondria, this triggers a cascade of beneficial cellular events.
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  5. Some potential effects are : neuroprotective effects, self-repair mechanisms and enhanced function.

Photonic Diffusion

A Pitzschke, B Lovisa, O Seydoux, M Zellweger, M Pfleiderer, Y Tardy and G Wagnières (2015). Red and NIR light dosimetry in the human deep brain., Federal Institute of Technology (EPFL), Institute of Chemical Sciences and Engineering (ISIC), 1015 Lausanne, Switzerland, Phys. Med. Biol. 60 (2015) 2921–2937

 

 
 
 
 

  1. Electromagnetic radiation within the 810nm wavelength is the most potent wavelength for diffusing through tissue, blood and brain.
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  3. The 810nm wavelength exhibits the least photonic scattering and absorption by blood|water in the entire electromagnetic spectrum.
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  5. Clinical studies have shown that NIR radiation of sufficient power density is capable of diffusing through the scalp, skull and brain to depths of 4 cm or more, transcranially and through the intranasal channel.

The Vielight Intranasal Advantage

A Pitzschke, B Lovisa, O Seydoux, M Zellweger, M Pfleiderer, Y Tardy and G Wagnières (2015). Red and NIR light dosimetry in the human deep brain., Federal Institute of Technology (EPFL), Institute of Chemical Sciences and Engineering (ISIC), 1015 Lausanne, Switzerland, Phys. Med. Biol. 60 (2015) 2921–2937

 
 
 

  1. Vielight’s patented intranasal stimulation technology and microchip LED technology is a powerful tool for brain photobiomodulation.
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  3. Why?
  • The intranasal channel lacks hair and skin, which are natural barriers for light energy.
  • Being just 3 inches from the brain, the intranasal channel is the most efficient channel for photobiomodulating the deeper, ventral brain area.
  • These deep structures within the brain’s core have important functions, such as long term memory and hormonal regulation.
  • Brain Photobiomodulation with the Vielight Neuro

    In-Depth Summary

    Mechanisms of Brain Photobiomodulation
    There are several mechanisms associated with promoting physiological change through photobiomodulation therapy (PBMT). The wavelengths primarily used with PBM is within the near-infrared range of the electromagnetic spectrum with a sufficient power density. When hypoxic/impaired cells are irradiated with low level NIR photons, there is increased mitochondrial adenosine tri-phosphate (ATP) production within their mitochondria.1, 2 Another change is the release of nitric oxide from the hypoxic/impaired cells. Neurons are cells that contain mitochondria and nitric oxide.

    In hypoxic neuronal cells, cytochrome-C oxidase (CCO), a membrane-bound protein that serves as the end-point electron acceptor in the cell respiration electron transport chain, becomes inhibited by non-covalent binding of nitric oxide. When exposed to NIR photons, the CCO releases nitric oxide, which then diffuses outs of the cell – increasing local blood flow and vasodilation.3, 4

    Following initial exposure to the NIR photons, there is a brief burst of reactive oxygen species (ROS) in the neuron cell, and this activates a number of signaling pathways. The ROS leads to activation of redox-sensitive genes, and related transcription factors including NF-κβ.5, 6 The PBMT stimulates gene expression for cellular proliferation, migration, and the production of anti-inflammatory cytokines and growth factors.7

    1. Karu T. Primary and secondary mechanisms of action of visible to near-IR radiation on cells. J Photochem Photobiol B 1999;49:1-17.
    2. Wong-Riley MT, Liang HL, Eells JT, Chance B, Henry MM, Buchmann E, Kane M, Whelan HT. Photobiomodulation directly benefits primary neurons functionally inactivated by toxins: role of cytochrome c oxidase. J Biol Chem 2005;280:4761-4771.
    3. Karu TI, Pyatibrat LV, Afanasyeva NI. Cellular effects of low power laser therapy can be mediated by nitric oxide. Lasers Surg Med 2005;36:307-314.
    4. Huang YY, Chen AC, Carroll JD, Hamblin MR. Biphasic dose response in low level light therapy. Dose Response 2009;7:358-383.
    5. Migliario M, Pittarella P, Fanuli M, Rizzi M, Reno F. Laser-induced osteoblast proliferation is mediated by ROS production. Lasers Med Sci 2014;29:1463-1467.
    6. Avci P, Gupta GK, Clark J, Wikonkal N, Hamblin MR. Low-level laser (light) therapy (LLLT) for treatment of hair loss. Lasers Surg Med 2014;46:144-151.
    7. Huang YY, Gupta A, Vecchio D, de Arce VJ, Huang SF, Xuan W, Hamblin MR. Transcranial low level laser (light) therapy for traumatic brain injury. J Biophotonics 2012;5:827-837.

    Vielight Devices

    Vielight 810

    The Vielight 810

     

  • The Vielight 810 is a non-laser intranasal brain photobiomodulation device.
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  • This device utilizes a cold diode (LED) to emit light energy within the near-invisible spectrum(810 nm) wavelength.
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  • Each session is auto-timed for 25 minutes, resulting in specific total irradiation with near-infrared photons of sufficient power density per cycle.
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    Vielight Neuro

    The Vielight Neuro

     

  • The Vielight Neuro is a next generation transcranial-intranasal brain photobiomodulation device.
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  • This device utilizes microchip LED technology to emit coherent light energy transcranially and intranasally within the near-invisible spectrum(810 nm) wavelength.
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  • Each session is auto-timed for 20 minutes, resulting in a relatively greater total irradiation with high-powered near-invisible photons per cycle.
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  • Our photobiomodulation devices combine solid state technology along with intranasal diodes built from transparent high-impact polycarbonate to ensure quality and durability – turning this into a lifetime investment.
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  • All Vielight Devices come with a 6-month satisfaction guarantee.