Vielight Research & Collaboration

Pulsed Near Infrared Transcranial and Intranasal Photobiomodulation Significantly Modulates Neural Oscillations: a pilot exploratory study
Institutes – Centre for Therapeutic Brain Intervention, Centre for Addiction and Mental Health, Toronto, Ontario, Canada

[ Published Study Link (Nature, Scientific Reports, 2019) ] (20 participants | 2 years | Published)

Effects of Home Photobiomodulation Treatments on Cognitive and Behavioral Function, Cerebral Perfusion, and Resting-State Functional Connectivity in Patients with Dementia: A Pilot Trial
Institutes – University of California San Francisco & the Veterans Affairs USA

[ Published Study Link (Photomedicine and Laser Surgery, 2018) ] (10 participants | 1 year | Published)

Significant Improvement in Cognition in Mild to Moderately Severe Dementia Cases Treated with Transcranial Plus Intranasal Photobiomodulation: Case Series Report
Co-authoring institutes – Harvard Medical School, Boston University School of Medicine

[ Published Study (Photomedicine and Laser Surgery, 2015) ] (5 participants | 1 year | Published)

Evaluation of dose of Photobiomodulation (Light) Therapy and Physiotherapy for Improving Quality of Life Outcomes and Mobility in Parkinson’s Disease (Pilot)
Institutes – University of Sydney, University of Brisbane

[ Clinical Trial Information Link (Australian New Zealand Clinical Trial Registry) ] (16 participants | 1.5 years | Starting)

Impact of Photobiomodulation (PBM) on Biomarkers of Alzheimer’s Disease
Institutes – University of California San Francisco

[ Clinical Trial Information Link ( – subsidiary of the US National Library of Medicine) ] (16 participants | 1.5 years | Starting)

Vielight Neuro RX Gamma – Pivotal Phase III Clinical Trial
Co-institutes – St Michael’s Hospital, Toronto

[ Clinical Trial Information Link ( – subsidiary of the US National Library of Medicine) ] (228 participants | 3 years | Ongoing)

Disclaimer: The research links below are independent information sources about photobiomodulation. No representation is made regarding Vielight devices or their capabilities.

Brain (transcranial) Photobiomodulation (tPBM)

Photobiomodulation Directly Benefits Primary Neurons Functionally Inactivated by Toxins
Medical College of Wisconsin : [ Link ]

Neuroprotective effects of photobiomodulation : Evidence from assembly/disassembly of the Cytoskeleton
University of Sydney : [ Link ]

Photon Penetration Depth in Human Brains
Institute of Biomedical Engineering, Chinese Academy of Medical Science : Link ]

Red and NIR light dosimetry in the human deep brain
Institute of Chemical Sciences and Engineering, Switzerland : [ Link 1 | Link 2 ]

Transcranial Red and Near Infrared Light Penetration in Cadavers
State University of New York Downstate Medical Center : [ Link ]

Quantitative analysis of transcranial and intraparenchymal light penetration in human cadaver brain tissue
Oregon Health and Science University : [ Link 1 | Link 2 ]

Review of brain photobiomodulation : targeting brain metabolism, inflammation, oxidative stress, and neurogenesis
Massachusetts General Hospital : [ Link ]

Shining light on the head : Photobiomodulation for brain disorders
Massachusetts General Hospital : [ Link ]

Augmentation of cognitive brain functions with transcranial lasers
Department of Psychology and Institute for Neuroscience, University of Texas : Link ]

Neurological and psychological applications of transcranial lasers and LEDs
Department of Neurology and Neurotherapeutics, University of Texas : Link ]

Photobiomodulation – mitochondrial ROS generation and calcium increase in neuronal synapses.
Lin-Kou Medical Center, Taiwan : [ Link ]

Infrared neural stimulation and functional recruitment of the peripheral Nerve
Department of Biomedical Engineering, Case Western Reserve University : [ Link ]

Photobiomodulation directly benefits primary neurons functionally inactivated by toxins
Dept. of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin : [ Link ]

A novel method of applying NIR light intracranially, impact on dopaminergic cell survival
University of Sydney, CEA-Leti : [ Link ]

Low Level Systemic (via blood) Photobiomodulation

Interplay between up-regulation of cytochrome-c-oxidase and hemoglobin oxygenation induced by near-infrared laser
University of Austin at Texas : [ Link ]

Molecular Targets for Photobiomodulation
Stanford University School of Medicine : Link ]

How Photons Modulate Wound Healing via the Immune System
King’s College London (KCL), University of London : [ Link ]

Randomized, Double-Blind, and Placebo-Controlled Clinic Report of Intranasal Low-Intensity Laser Therapy on Vascular Diseases
Ministry of Education, Key Laboratory of Laser Life Science, China : [ Link ]

Blood Laser Irradiation : current state and future perspectives
ABER Institute, Helsinki, Finland : [ Link ]

Intravenous Laser Blood Irradiation
MH Weber : [ Link ]

Applications of Intranasal Low Intensity Laser Therapy In Sports Medicine
Journal of Innovative Optical Health Sciences, World Scientific : [ Link ]

Formation of gigantic mitochondria in human blood lymphocytes under the effect of a low level laser source
Institute on Laser and Informatic Technologies of Russian Acad. : [ Link ]

Irradiation with He-Ne laser increases ATP level in cells cultivated in vitro
National Cancer Research Centre of the Academy of Medicine and Science : [ Link ]

Photobiomodulation Mechanisms

Mitochondrial Mechanisms of Photobiomodulation – Multiple Roles of ATP : Link ]

Therapeutic Photobiomodulation: Nitric Oxide and a Novel Function of Mitochondrial Cytochrome C Oxidase : [ Link ]

Mechanisms of Low Level Light Therapy : [ Link ]

Basic Photomedicine : [ Link ]

The Nuts and Bolts of Low Level Light Therapy : [ Link ]